FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans
نویسندگان
چکیده
منابع مشابه
The Flightless I homolog, fli-1, regulates anterior-posterior polarity, asymmetric cell division and ovulation during C. elegans development
Flightless I (Fli I) is an evolutionarily conserved member of the gelsolin family, containing actin binding and severing activity in vitro. The physiological function of Fli I during animal development remains largely undefined. In this study, we reveal a key role of the C. elegans Fli I homolog, fli-1, in specifying asymmetric cell division and establishing anterior-posterior polarity in the z...
متن کاملPost-embryonic expression pattern of C. elegans let-60 ras reporter constructs
let-60 ras plays roles in the differentiation of several C. elegans tissues (Yochem, J., Sundaram, M., Han, M., 1997. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans. Mol. Cell. Biol. 17, 2716-2722). To understand the transcriptional regulation of ras and to identify new functions for ras in development, we examined expression patte...
متن کاملLET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans.
The DAF-2 insulin/insulin-like growth factor 1 (IGF-1) receptor signals via a phosphatidylinositol 3-kinase (PI3K) pathway to control dauer larva formation and adult longevity in Caenorhabditis elegans. Yet epistasis analysis suggests signal bifurcation downstream of DAF-2. We have used epistasis analysis to test whether the Ras pathway (which plays a role in signaling from mammalian insulin re...
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Proper coordination of oogenesis, ovulation, and fertilization is essential for successful reproduction. In Caenorhabditis elegans, a strong loss-of-function mutation in dpl-1, which encodes a subunit of the E2F heterodimeric transcription factor EFL-1/DPL-1, causes severe defects during ovulation and fertilization. Here we demonstrate that the somatic gonad structure and sheath cell contractio...
متن کاملSuppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.
The let-60 ras gene of Caenorhabditis elegans is one of the key players in a signal transduction pathway that controls the choice between vulval and epidermal differentiation in response to extracellular signals. To identify components acting downstream of let-60 ras in the vulval signaling pathway, we have identified a reduction-of-function mutation in the sur-1 gene that completely suppresses...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2008
ISSN: 1471-213X
DOI: 10.1186/1471-213x-8-54